In 2020, the Chinese Ministry of Ecology and Environment (MEE) issued Order No. 12, replacing MEP Order No. 7. New measures for environmental management registration of chemical substances require different registration types for new substances not listed in the Inventory of Existing Chemical Substances of China (IECSC) and for substances listed in the IECSC but used for industrial applications other than permitted uses in order to be researched, manufactured, imported, processed and used in the territory of the People’s Republic of China (PRC). Registration is not mandatory for mixtures (formulations). However, if the substances that make up a mixture are considered new substances, they must be registered. This also applies to variable component substances and complex reaction products without unique and definite molecular structures. Polymers are not exempt from registration.